Home / Best-of lists / Best Licorice Root Extract Treatments
Best-of · Updated May 2026

Best Licorice Root Extract Treatments

This list contains 14 products formulated with licorice root extract. Analysis of the top-ranked products, including Regenacalm Retinol Serum S1 Pro and Tranexamic Topical Acid 5%, shows frequent co-occurrence of licorice root with ingredients such as vitamin c, niacinamide, salicylic acid, tranexamic acid, lactic acid, retinol, and hyaluronic acid. The price of these treatments ranges from $13 to $130, with an average price of $48. These products represent a variety of formulations centered around the primary ingredient.

Products ranked
14
Scoring scale
/100
Sponsored picks
0
Last updated
May 2026
Top pick
Rank
01
Facetheory Regenacalm Retinol Serum S1 Pro 30 ml amber glass bottle
Facetheory · treatment

Regenacalm Retinol Serum S1 Pro

High-Dose Retinol Value Pick

A legitimately high-dose 3% encapsulated retinol serum that delivers prescription-adjacent results at an unusually low price, buffered enough by licorice, dill, ferulic, and vitamin C to actually be wearable. Not a first…

indieFragrance FreeParaben FreeCruelty Free
85 /100
Price $38.00
Size 30 ml
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Rank
02
Naturium Tranexamic Topical Acid 5% frosted glass bottle with dropper
Naturium · treatment

Tranexamic Topical Acid 5%

Multi-Pathway Dark Spot Eraser

Naturium's Tranexamic Topical Acid 5% is a remarkably well-constructed brightening serum that tackles hyperpigmentation from four different biochemical angles for just $20. It mirrors the multi-active approach that derma…

indieFragrance FreeParaben FreeCruelty Free
81 /100
Price $20.00
Size 1 oz / 30 mL · other sizes available
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Rank
03
Jan Marini Age Intervention Retinol Plus bottle
Jan Marini · treatment

Age Intervention Retinol Plus

Professional-Tier Retinol Pick

A professional-grade 0.5% retinol with a thoughtfully engineered calming and barrier-support system — one of the better-constructed OTC retinol formulas for patients who want clinical results without prescription tretino…

professionalFragrance FreeParaben FreeCruelty Free
80 /100
Price $90.00
Size 30ml
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Rank
04
Paula's Choice 10% Azelaic Acid Booster in a white and green squeezable tube
Paula's Choice · treatment

Azelaic Acid Booster

Redness & Brightening Multitasker

A genuinely multitasking treatment that earns its place in routines targeting redness, acne marks, and uneven tone. The 10% azelaic acid concentration delivers real results backed by decades of clinical research, though …

gelclinicalFragrance FreeParaben Free
76 /100
Price $36.00
Size 1 fl oz / 30 mL · other sizes available
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Rank
05
Peace Out Skincare Dark Spots Brightening Dots microneedling patch package
Peace Out Skincare · treatment

Dark Spots Brightening Dots

Targeted Treatment Innovator

An innovative delivery format that puts clinically respected brightening ingredients — tranexamic acid, niacinamide, arbutin, and licorice — directly past the skin barrier via dissolving microneedles. The science behind …

indieFragrance FreeParaben FreePregnancy Safe
73 /100
Price $28.00
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Rank
06
Paula's Choice 10% Azelaic Acid Booster in white squeeze tube with green cap
Paula's Choice · treatment

10% Azelaic Acid Booster

Rosacea & Dark Spot MVP

The most elegantly formulated OTC azelaic acid product available — a 10% concentration backed by synergistic brightening, soothing, and exfoliating ingredients in a fragrance-free, vegan, cruelty-free package. The versat…

gelclinicalFragrance FreeParaben Free
70 /100
Price $39.00
Size 1 fl oz (30 mL) · other sizes available
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Rank
07
Ole Henriksen Invigorating Night Transformation Gel green jar
Ole Henriksen · treatment

Invigorating Night Transformation Gel

OG Night Exfoliator (Discontinued)

The OG overnight acid treatment that established Ole Henriksen's reputation for sleep-and-glow skincare. Now discontinued in favor of the Dewtopia line, this potent glycolic-lactic gel delivered undeniable morning-after …

clinicalParaben FreePregnancy SafeCruelty Free
70 /100
Price $45.00
Size 1.7 oz · other sizes available
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Rank
08
Paula's Choice Clinical 20% Niacinamide Treatment in an opaque tube
Paula's Choice · treatment

20% Niacinamide Treatment

Maximum Strength Pore Treatment

A bold escalation product for stubborn pore concerns that pushes niacinamide to its commercial ceiling. The supporting formula is thoughtful, the gel texture is well-suited for targeted use, and results for persistent en…

clinicalFragrance FreeParaben FreePregnancy Safe
68 /100
Price $54.00
Size 0.67 fl oz
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Rank
09
Fenty Skin Blemish Defeat'r BHA Spot-Targeting Gel in a compact squeeze tube
Fenty Skin · treatment

Blemish Defeat'r BHA Spot-Targeting Gel

Innovative Spot Treatment

A smartly formulated dual-BHA spot treatment with genuinely innovative film-forming technology that solves the 'spot treatment under makeup' problem. The formulation earns respect, but the small size, premium price, and …

indieFragrance FreeParaben FreePregnancy Safe
67 /100
Price $25.00
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Rank
10
PCA Skin Pigment Gel Pro dark spot corrector pump bottle
PCA Skin · treatment

Pigment Gel Pro

Hydroquinone-Free Brightening Powerhouse

The most scientifically ambitious hydroquinone-free dark spot corrector on the professional market, attacking pigmentation through five separate biochemical pathways. The actives are genuinely impressive — the vehicle is…

clinicalParaben FreeCruelty Free
67 /100
Price $130.00
Size 1 oz / 29.5 ml
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Rank
11
Sunday Riley UFO Ultra-Clarifying Acne Treatment Face Oil in a green glass dropper bottle
Sunday Riley · treatment

UFO Ultra-Clarifying Acne Treatment Face Oil

Acne Oil Pioneer

U.F.O. is a genuinely innovative acne treatment that rethinks how salicylic acid should be delivered — but at $80 for a modest 1.5% BHA concentration, the creative formulation philosophy costs significantly more than the…

indieParaben FreeCruelty FreeVegan
65 /100
Price $80.00
Size 1.18 oz / 35 mL · other sizes available
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Rank
12
Bioderma Sébium Global Intensive Care 30ml tube with green Sebium line branding
Bioderma · treatment

Sébium Global Intensive Care

Multi-Mechanism Acne Fighter

The most scientifically ambitious OTC acne treatment you'll find in a pharmacy — six active mechanisms in one tube, backed by an actual published clinical trial. Best for oily, acne-prone skin that can tolerate aggressiv…

pharmacy brandParaben FreeNot Cruelty Free
63 /100
Price $25.99
Size 30 ml
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Rank
13
Palmer's Cocoa Butter Formula Eventone Dark Spot Corrector in small dark bottle with dropper
Palmer's · treatment

Cocoa Butter Formula Eventone Dark Spot Corrector

Budget Brightening Multi-Active

A surprisingly sophisticated multi-active brightening serum at a drugstore price, combining five distinct melanin-targeting pathways. The hexylresorcinol and songyi mushroom extract duo is genuinely interesting, but the …

drugstoreParaben FreePregnancy SafeNot Cruelty Free
61 /100
Price $12.99
Size 1 fl oz / 30 ml
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Rank
14
Bobbi
Bobbi Brown · treatment

Remedies Skin Salve Restoring Treatment

Luxury Skin Rescue Balm

A conceptually smart rescue balm that paired a clinical-grade petrolatum-beeswax occlusive with genuine barrier repair actives — ceramide NG, cholesterol, centella, and licorice — in a luxury package. The formulation ear…

luxuryParaben FreeNot Cruelty Free
52 /100
Price $45.00
Size 0.59 oz
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How we picked these.

Scores combine ingredient quality, real-world wear data from independent communities, irritation reports, and value per ounce. We don't accept paid placements; ranks come from the data alone.

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