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Best-of · Updated May 2026

Best Beta-Glucan Serums

This list identifies eight products formulated with beta-glucan. Analysis of the top-ranked products, including the Pine Tree Calming Cica Ampoule and Heartleaf 80% Soothing Ampoule, shows frequent combinations of beta-glucan with centella asiatica, niacinamide, panthenol, probiotics, prebiotics, hyaluronic acid, peptides, and pine extract. Prices for these serums range from $22 to $200, with an average cost of $51. These formulations typically integrate beta-glucan alongside various soothing and hydrating components.

Products ranked
8
Scoring scale
/100
Sponsored picks
0
Last updated
May 2026
Top pick
Rank
01
Round Lab Pine Tree Calming Cica Ampoule in a small green and white bottle with pump
ROUND LAB · serum

Pine Tree Calming Cica Ampoule

Derm Office Staple

One of the more rigorously formulated calming ampoules in K-beauty — a proper TECA cica complex on a pine extract base with panthenol, niacinamide, and beta-glucan. Fragrance-free, fungal acne safe, and genuinely useful …

k beautyFragrance FreeParaben FreePregnancy Safe
86 /100
Price $22.00
Size 50 ml / 1.69 fl oz
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Rank
02
SKIN1004 Probio-Cica Intensive Ampoule 50ml dropper bottle — postbiotic centella treatment serum
SKIN1004 · serum

Probio-Cica Intensive Ampoule

Barrier Rescue Ampoule

The treatment-tier centerpiece of SKIN1004's Probio-Cica line — a centella ampoule that layers four postbiotic ferments, polyglutamic acid, and a small ceramide trio onto the full triterpene panel. If you want a barrier-…

k beautyFragrance FreeParaben FreePregnancy Safe
85 /100
Price $32.00
Size 50ml
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Rank
03
Abib Heartleaf Essence Calming Pump in a 75ml frosted pump bottle
Abib · serum

Heartleaf Essence Calming Pump

K-Beauty Calming Essence Pick

Abib's Heartleaf Essence Calming Pump is the strongest single product in the brand's Heartleaf line — 78% Houttuynia cordata base in an essence format that gives the actives more contact time than the toner does, layered…

k beautyFragrance FreeParaben FreePregnancy Safe
84 /100
Price $27.00
Size 50ml · other sizes available
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Rank
04
SKIN1004 Tea-Trica Relief Ampoule 50ml dropper bottle — tea tree and BHA acne treatment serum
SKIN1004 · serum

Tea-Trica Relief Ampoule

Acne Treatment Ampoule

The treatment-tier anchor of SKIN1004's Tea-Trica line — a tea-tree-water-based ampoule that carries a treatment-grade betaine salicylate dose plus the full centella triterpene panel and beta-glucan for buffering. For oi…

k beautyFragrance FreeParaben FreeCruelty Free
83 /100
Price $26.00
Size 30ml
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Rank
05
Anua Heartleaf 80% Soothing Ampoule in a glass dropper bottle with white cap
Anua · serum

Heartleaf 80% Soothing Ampoule

Calm-Down Concentrate

A concentrated, featherweight soothing ampoule that delivers Anua's highest heartleaf concentration alongside a smart microbiome-supporting reformulation. Best for sensitive and reactive skin types who want a dedicated c…

k beautyFragrance FreeParaben FreePregnancy Safe
81 /100
Price $26.00
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Rank
06
CNP Laboratory Propolis Energy Ampule amber glass bottle with pipette dropper
CNP Laboratory · serum

Propolis Energy Ampule

K-Beauty Derm Clinic Staple

A legitimately propolis-forward ampoule that has earned its place as one of the longest-running K-beauty cult products by actually delivering on its ingredient story. The tacky finish and honey scent will divide users, b…

k beautyParaben FreePregnancy SafeNot Cruelty Free
80 /100
Price $35.00
Size 15ml · other sizes available
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Rank
07
Dr. Jart+ Vital Hydra Solution Capsule Ampoule individual hydrating capsules
Dr. Jart+ · serum

Vital Hydra Solution Capsule Ampoule

Hydration Emergency Kit

A beautifully engineered intensive hydration treatment that packs five molecular weights of hyaluronic acid into a pharmaceutical-inspired capsule format. The seaweed-first formula, complete absence of irritants, and gen…

k beautyFragrance FreeParaben FreePregnancy Safe
80 /100
Price $42.00
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Rank
08
ZO Skin Health Growth Factor Serum 1 oz airless pump bottle
ZO Skin Health · serum

Growth Factor Serum

Post-Procedure Favorite

ZO Growth Factor Serum is one of the smarter products in the category because it hedges the growth factor evidence base with a supporting-dose retinol, a real peptide, and a comfort-focused delivery system. The plant gro…

dermatologist developedParaben FreeNot Cruelty Free
72 /100
Price $200.00
Size 1 fl oz / 30 ml
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How we picked these.

Scores combine ingredient quality, real-world wear data from independent communities, irritation reports, and value per ounce. We don't accept paid placements; ranks come from the data alone.

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