Multi-Peptide + HA Serum
The Anti-Aging All-Rounder
Verified reviewer
Pros & cons.
- +Five peptide technologies targeting expression lines, structural proteins, and collagen degradation simultaneously
- +Fewer use restrictions than Copper Peptides version — compatible with retinoids
- +Comprehensive NMF complex with eleven amino acids provides meaningful hydration support
- +Available in 60ml size for better value and 4-6 months of sustained use
- +No unusual color or metallic odor — significantly more cosmetically elegant than the copper version
- +Lightweight, fast-absorbing texture that layers cleanly under any routine
- −Still cannot be combined with direct acids or vitamin C in the same routine
- −Peptide results require 4-12 weeks of patience with no immediate visible anti-aging effects
- −Some users report burning, irritation, or breakouts — individual reactions vary
- −Limited review count on the reformulated version makes real-world assessment less certain
- −Results can be subtle enough that some users question whether the product is working
The full review.
Peptide serums used to be either very expensive or very disappointing. Then The Ordinary released Buffet, a name reflecting its “pile everything on” philosophy and high price-to-performance ratio. The product is now the Multi-Peptide + HA Serum, but the DNA remains: it uses every proven peptide technology to target aging and lets the user decide if the results justify the approach.
The approach is comprehensive. Five distinct peptide technologies are present: Acetyl Hexapeptide-8 (Argireline), which modulates neuromuscular signals behind expression lines; Pentapeptide-18, which complements Argireline via a different neurotransmitter pathway; Palmitoyl Tripeptide-38 (Matrixyl synthe’6), which stimulates six structural proteins in the dermal matrix; the Palmitoyl Tripeptide-1 and Tetrapeptide-7 duo (Matrixyl 3000), which boosts collagen and reduces inflammation; and Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake), a venom-mimicking peptide that targets muscle relaxation. Each addresses a different aging mechanism. Together, they act like a topical combination therapy.
The Multi-Peptide + HA Serum differs from its more expensive sibling — the Multi-Peptide + Copper Peptides 1% Serum — by what it lacks. Without copper tripeptide-1, there is no blue color, no metallic smell, no restriction against retinoids, and the price is $12 lower. For many, these absences are features. The Copper Peptides version requires routine restructuring; this version only requires you to avoid direct acids and vitamin C in the same sitting. This constraint is more manageable and still allows for retinoids, the gold standard of anti-aging.
The supporting formula shows The Ordinary’s thoughtfulness. Lactococcus Ferment Lysate provides a probiotic-derived matrix of amino acids and growth factor-like molecules. Eleven amino acids plus a full complement of NMF components — urea, sodium PCA, sodium lactate, and sugars — replenish the skin’s natural hydration infrastructure. Dual-form hyaluronic acid (standard and crosspolymer) provides immediate and sustained moisturization. Allantoin adds soothing and skin-conditioning properties. The delivery vehicle is engineered to support both the actives and the skin.
The texture is lightweight and undemanding. This clear serum has a slight gel consistency and absorbs quickly without stickiness, greasiness, or visible residue. It has no metallic smell, no unusual color, and no sensory drama. It layers cleanly under moisturizer and sunscreen. The 60ml size is a welcome addition to the reformulated product; it makes economic sense for a twice-daily serum and lasts four to six months.
Results follow the standard peptide timeline, so manage your expectations. Peptides signal your skin’s biological machinery to produce more collagen, assemble more structural proteins, and reduce inflammatory processes that degrade existing structures. These are real biological processes that operate at biological speed, not marketing speed. Hydration improves immediately. Texture smooths within a couple of weeks. Fine-line reduction becomes noticeable at four to eight weeks. Meaningful firmness and elasticity improvement requires eight to twelve weeks of consistent use.
Many users stop using peptide products during this timeline. Unlike immediate-gratification actives — retinoids that peel within days, AHAs that brighten overnight, or vitamin C that delivers an instant glow — peptides require you to trust a process you cannot see. Users who stick with this product and report positive results are those who gave it the two to three months it needs. Those who abandoned it after two weeks would not have seen its effects.
The Ulta review count (around 100) reflects the product’s recent reformulation rather than low interest. The original Buffet was one of The Ordinary’s global bestsellers, and the reformulated version inherits that reputation while updating the delivery technology. Early reviews are positive for those who gave it adequate time. Main complaints center on individual sensitivity reactions (burning or breakouts), suggesting this formula does not work for every skin type.
At $19.90 — or less per ml in the 60ml size — this is among the most affordable multi-peptide serums from any reputable brand. The five peptide technologies would cost $60-120 from most competitors. The supporting ingredient profile (ferment lysate, full amino acid complex, dual HA) adds value that the price barely reflects.
The Multi-Peptide + HA Serum is the anti-aging product for the pragmatist. It won’t reorganize your routine, assault your senses, or deliver overnight miracles. If you provide the required time and consistency, it addresses aging from five biochemical angles at a sustainable price. It is not an exciting sales pitch, but it is an honest one.
Ingredient analysis.
Full INCI list
Aqua (Water), Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin
Skin match.
The science.
The Science
Five peptide technologies target different skin aging mechanisms using a multi-vector approach.
Blanes-Mira et al. published a study in the International Journal of Cosmetic Science (2002) on Acetyl Hexapeptide-8 (Argireline). The study shows this peptide inhibits SNARE complex formation, the molecular machinery driving neurotransmitter release at the neuromuscular junction. It decreases the intensity of muscle contractions that create expression lines by reducing catecholamine exocytosis. Acetyl Hexapeptide-8 is less potent than injectable neurotoxins, but it is a validated topical approach to dynamic wrinkle reduction.
The Matrixyl peptides (Palmitoyl Tripeptide-1/Tetrapeptide-7 and Palmitoyl Tripeptide-38) use signaling pathways. Sederma developed Palmitoyl Tripeptide-38, which stimulates synthesis of collagen I, III, IV, fibronectin, hyaluronic acid, and laminin-5—six structural components that decline with age. The Palmitoyl Tripeptide-1/Tetrapeptide-7 duo uses a complementary mechanism: the tripeptide mimics a collagen fragment to signal fibroblasts to produce new collagen, while the tetrapeptide suppresses IL-6 production, an inflammatory cytokine that promotes matrix metalloproteinase activity and collagen degradation.
The amino acid and NMF complex has a distinct function here. Research shows the skin's natural moisturizing factor—composed of amino acids, PCA, lactate, urea, and sugars—declines with age and environmental exposure. This formula replenishes these components topically to support the skin's intrinsic hydration capacity while the peptides work on structural repair. Optimally hydrated skin shows wrinkles less prominently and provides a better substrate for peptide activity.
References
- A synthetic hexapeptide (Argireline) with antiwrinkle activity — International Journal of Cosmetic Science (2002)
Dermatologist Perspective
Dermatologists view multi-peptide serums as a valid supplement to anti-aging, especially for patients who cannot tolerate retinoids or prefer a gentler strategy. Board-certified dermatologists note that the peptide technologies in this formula—specifically Matrixyl and Argireline—have published research supporting their efficacy at cosmetic concentrations, though they note peptides are generally less potent than prescription retinoids for collagen stimulation. The formula's compatibility with retinoids (unlike the copper peptides version) is clinically relevant; patients can use this serum as a morning complement to an evening retinoid to address aging through multiple mechanisms without conflict. Dermatologists find the extensive NMF and amino acid complex beneficial for skin hydration and barrier function.
Where it fits in your routine.
Apply a few drops to a clean face every morning and evening before moisturizer. Avoid using it with direct acids, direct vitamin C, resveratrol and ferulic acid, or salicylic acid. You can layer it over retinoids at night (check The Ordinary's regimen guide for specific product compatibility). Let the serum absorb for 1-2 minutes before you apply moisturizer. Patch test before first use.
At $19.90 for 30ml, or less per ml in the 60ml size, this serum provides five peptide technologies, a probiotic ferment lysate, eleven amino acids, full NMF replenishment, and dual-form hyaluronic acid for less than most single-peptide serums. The value beats the Copper Peptides version; for $12 less, you lose the copper tripeptide but gain retinoid compatibility and a more versatile routine. The 60ml size is economical for long-term use, costing about 15-20 cents per application at twice-daily use.
This is a comprehensive anti-aging serum at an accessible price. It works well for retinoid users seeking a compatible peptide product. It suits people in their late 20s-50s who want to target early-to-moderate signs of aging using a multi-peptide approach without changing their whole routine.
Those wanting immediate anti-aging results should wait; peptides take 4-12 weeks of consistent use. People who had sensitivity to the original Buffet formula. Users happy with a simple retinoid + sunscreen routine who want no extra steps. The Copper Peptides version works better for those restructuring their routine for maximum peptide coverage.
Product details.
This clear, lightweight aqueous serum has a slight gel-like consistency. It absorbs quickly and leaves no stickiness or residue.
Virtually unscented — no noticeable fragrance or metallic note (unlike the Copper Peptides version)
Frosted glass dropper bottle with white pipette cap — comes in 30ml and 60ml sizes
Most users experience a smooth, comfortable application with no tingling, stinging, or sensation. It provides an immediate hydration boost. This formula lacks the blue color or metallic smell of the Copper Peptides sibling. Most users add this to their routine without an adjustment period. Anti-aging benefits show over 4-12 weeks.
2-3 months with twice-daily use (30ml); 4-6 months with 60ml
12 months
All Year
The backstory.
Originally known as 'Buffet' — a name that perfectly captured its everything-but-the-kitchen-sink approach to peptide formulation — this was one of The Ordinary's most beloved and best-selling products. The reformulation under the Multi-Peptide name updated the peptide technologies and delivery system while maintaining the spirit of the original: throw every proven peptide technology at aging and see what sticks. The 60ml size option was added to address the original's most common complaint — that the 30ml ran out too quickly.
About The Ordinary
Established Brand (5–20 years)DECIEM launched The Ordinary in 2016. It is now a top name in affordable, ingredient-focused skincare. The brand does not run proprietary clinical trials on its specific formulations, but it uses well-studied actives at transparent concentrations. This approach earns widespread dermatologist acknowledgment.
FAQ.
What's the difference between Multi-Peptide + HA and Multi-Peptide + Copper Peptides?
The Multi-Peptide + HA ($19.90) contains five peptide technologies without copper tripeptide-1. The Copper Peptides version ($32) adds GHK-Cu at 1% but comes with more use restrictions — it can't be combined with retinoids or vitamin C. If you use retinoids or vitamin C, the HA version is the better fit. If you want maximum peptide coverage and are willing to restructure your routine, the Copper Peptides version offers more.
Can I use this serum with retinol?
Yes, with caution. This formula works with retinoids, unlike the Copper Peptides version, but The Ordinary recommends checking their regimen guide for specific compatibility. Many users apply this serum over their retinoid in the evening for hydration and peptide support, or use it in the morning while the retinoid goes at night.
Is this the same as the old Buffet serum?
This reformulated successor replaces the original. The Multi-Peptide + HA Serum uses the same core peptide technologies as Buffet — Matrixyl, Argireline, and the amino acid and NMF complex — but uses updated delivery systems and a refined base. The philosophy is the same: target aging from multiple peptide angles at once.
How long does it take to see results from this peptide serum?
Peptides drive biological processes like collagen synthesis and structural protein production. These changes take weeks to show. Expect immediate hydration, subtle texture and firmness changes at 4-8 weeks, and fine-line reduction at 8-12 weeks. Use them twice daily; occasional use lacks the peptide signaling needed for visible results.
Can I use this with vitamin C?
Do not use these in the same routine. The Ordinary advises against mixing this serum with direct vitamin C (L-ascorbic acid). Use the peptide serum in the morning and vitamin C in the evening, or alternate days. Vitamin C derivatives like ascorbyl glucoside may be less restrictive, but separate them to be safe. ---
Community
What the community says.
"Visible improvement in skin firmness, hydration, and elasticity with consistent use"
"Lightweight texture that absorbs well without greasiness or residue"
"Good value for a multi-peptide serum compared to luxury competitors"
"Less restrictive than the Copper Peptides version for routine building"
"Some users report burning or irritation upon application"
"Results can be subtle and difficult to attribute specifically to this product"
"A few users experienced breakouts during the initial use period"
"Peptide benefits require weeks of patience that some users lack"
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