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Differin

Differin Adapalene Gel was a prescription-only medication from 1996 until the FDA approved its OTC switch in July 2016, making it the first and only prescription-strength retinoid available without a prescription. The approval was based on 20 years of safety data from over 40 million patients globally. Manufactured by Galderma, a global dermatology company with R&D headquarters in Sophia Antipolis, France.

DermFND
Verified house
8 of 9 products signed off
Products reviewed
9
Average score
69.9/100
Median price
$15
Top category
moisturizer
Last reviewed
May 2026
Alex Brufsky
Alex Brufsky Founder & Editor
Analysis by DermFND · Last verified May 2026 · Methodology
Verified reviewer
9 products viewing all categories
The DermFND take

Differin, by the numbers.

Differin has 9 products in the DermFND database, concentrated in moisturizers and cleansers. Observed ingredient patterns across the product range include adapalene, ceramides, niacinamide, glycerin, panthenol, witch hazel, retinoid, and hyaluronic acid. Based on the price range of $11 to $22, the brand maintains an average price point of $16. The typical product profile includes items such as Adapalene Gel 0.1%, Restorative Night Moisturizer, Oil Absorbing Moisturizer SPF 30, Gentle Cleanser, and Soothing Moisturizer. The average DermFND score for these products is 69.9/100.

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